Estudio que recuerda los efectos de supresión de estatinas ( remedios para reducir el colesterol). Al igual que nos recuerda la visión de la homeopatía clásica.
Statins withdrawal, vascular complications, rebound effect and similitude
Received 4 July 2009;
revised 12 January 2010;
accepted 31 January 2010.
Available online 20 October 2010.
Hahnemann considered the secondary action of medicines to be a law of nature and reviewed the conditions under which it occurs. It is closely related to the rebound effects observed with many modern drugs. I review the evidence of the rebound effect of statins that support the similitude principle. In view of their indications in primary and secondary prevention of cardiovascular diseases, statins are widely prescribed. Besides reducing cholesterol biosynthesis, they provide vasculoprotective effects (pleiotropic effects), including improvement of endothelial function, increased nitric oxide bioavailability, antioxidant properties, inhibition of inflammatory and thrombogenic responses, stabilisation of atherosclerotic plaques, and others. Recent studies suggest that suspension of statin treatment leads to a rebound imparing of vascular function, and increasing morbidity and mortality in patients with vascular diseases. Similarly to other classes of modern palliative drugs, this rebound effect is the same as a secondary action or vital reaction described by Samuel Hahnemann, and used in homeopathy in a therapeutic sense.
Keywords: Similitude; Secondary effect; Rebound effect; Paradoxical reaction; Substance withdrawal syndrome; Statin; Vascular diseases; Homeopathy