JENGIBRE

Es uno de mis favoritos, lo recomiendo frecuentemente y aveces siento que lo hago con mucha frecuencia en mi trabajo. Lo aprendí a recomendar al estudiar macrobiótica. Este estudia nos da soportes y alientos para seguirlo consumiendo y recomendando.
No olvidemos lo útiles que son las compresas en situaciones locales y sistémicas.

Ginger Modulates Lymphocyte Activity in Vitro and in Vivo and Modestly Prolongs Cardiac Allograft Survival

Chumpon Wilasrusmee, Department of Surgery, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Smita Kittur, SUNY Upstate Medical Univeristy
Sudipta Tripathi, SUNY Upstate Medical Univeristy
Gaurang Shah, SUNY Upstate Medical University
David Bruch, SUNY Upstate Medical University
Dilip S. Kittur, SUNY Upstate Medical University

Abstract

Objectives: Ginger, an herb with diverse pharmacotherapeutic properties, is used as an anti-inflammatory agent in immunological disorders like rheumatoid arthritis. The objective of the present investigation was to study the effect of ginger on alloreactivity and on prolongation of cardiac allograft in mice.

Design: We tested the effect of ginger extract on lymphocytes in vitro and in vivo and the response of ginger treated lymphocytes to allostimulation and cytosine release. We also studied the effect of ginger extract on cardiac allograft survival in a non vascularized transplantation model in mice.

Results: We observed an immunosuppressive effect of ginger in vitro and in vivo. Ginger extract decreased lymphocyte proliferation in response to allostimulation. Ginger extract also decreased the production of the immunostimulatory cytokines IL-2, IL-4 and IFN-γ and increased the production of the immunomudulatory cytokines IL-10 and TGFβ1. Ginger extract by itself produced a modest increase in the survival of cardiac allografts in mice survival.

Conclusion: Our study demonstrates that ginger extract has immunosuppressive effects both in vitro on lymphocyte proliferation and cytokine production and in vivo on allograft survival.

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